Norway Grants
Norway Grants
Huntington's disease (HD) is a serious neurodegenerative disease that is caused by a mutation in the first exon of the gene encoding the protein huntingtin. The mutation affects a polymorphic region where CAG trinucleotides are repeated and is passed on to offspring by autosomal, dominant inheritance. Numerous studies in mouse models have elucidated important metabolic pathways that are adversely affected, while clarifying the pathogenesis of HD. However, the exact mechanism by which mutated huntingtin causes selective neurodegeneration is still unclear. The grant proposal is based on a comparative study of both tissues, especially brain, and somatic (skin fibroblasts) and germ cells (sperm) isolated from transgenic mice (R6 / 2), transgenic minipigs for the N-terminal part of human mutant huntingtin (TgHD) and HD patients. This unique biological material will be investigated in a comprehensive set of biochemical, immunocytochemical and molecular genetic methods in collaboration with four laboratories, two Norwegian and two Czech. Tissue instability of the CAG sequence will be monitored by DNA from R6 / 2 mouse, F2 and F3 tissues by generation TgHD minipigs. A comprehensive methodological approach to mitochondrial functions and Golgi apparatus proteins will be implemented on the brain tissue of mice and minipigs (F2 generation) and on the cells of mice, minipigs and HD patients. The process of gradual aggregation of mutated huntingtin will be monitored on mouse and minipig brain tissue (F2 generation) and R6 / 2 mouse cells and on F0 and F1 generations of TgHD minipigs.
The University in Prague was founded by a charter issued on 7 April 1348 by Charles IV, King of Bohemia and King of the Romans. Charles University is thus one of the oldest European universities. There are currently 17 faculties at the University, It is the largest Czech university. University offer over 600 different courses, covering a wide spectrum of disciplines (from medical sciences and life sciences to social sciences and humanities and after theological studies, including the study of teaching). Charles University is a research-oriented institution that is continuously developing scientific cooperation and takes part in European and international programs.
The University of Oslo is tle oldest and largest university in Norway. The University of Oslo was founded in 1811 as the first in Norway and according to the latest Danish-Norwegian King Frederik VI. was named The Royal Frederick University. UiO has eight faculties: Faculty of Medicine, Faculty of Dentistry, Faculty of Law, Faculty of Theology, Faculty of Humanities, Faculty of Mathematics and Natural Sciences, Faculty of Social Sciences, Faculty of Education Sciences. UiO has top research communities in most areas. UiO is the highest ranked institution of education and research in Norway with five Nobel Prize winners
The hospital is Scandinavia’s largest and we each year carry out more than 1.2 million patient treatments. The Hospital was founded January 1, 2009 by merger of of Aker University Hospital, Rikshospitalet University Hospital and Ullevål University Hospital. Oslo University Hospital is responsible for approximately 50 percent of all medical and healthcare research conducted at Norwegian hospitals and is a significant role player within the education of a large variety of health care personnel.
