Collaboration
Collaboration
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Aarhus University, Institute of Anatomy, Department of Biomedicine | Carsten Bjarkam & Team | Collaboration with Carsten Bjarkam, MD., PhD., and his team was a key factor in to our efforts to develop an acute pig model of Huntington's disease. Carsten and his team work with porcine model of Parkinson's disease. Thanks to Carsten´s help and experience, we have created a stereotactic device that is used to inject the vector molecules into the pig's brain. Carsten also helped us with the methodology of the preparation of the brain for subsequent histochemical analyses. Carsten is actively involved in the organization of Large Animal Models of Neurodegenerative Diseases Conferences. | |
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Charles University and General University Hospital in Prague, Department of Neurology | Jiri Klempir, Jan Roth & Team | Jiri Klempir, Jan Roth & Team | |
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Charles University and General University Hospital in Prague, Department of Pediatrics and Adolescent Medicine, Laboratory for Study of Mitochondrial Disorders | Hana Hansikova & Team | Hana Hansikova, MD., PhD., and her team focus on mitochondrial damage and help us with characterization of the disease progress of our transgenic model of Huntington´s disease. | |
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CHDI Foundation "Cure-Huntington's Disease Initiative Foundation" | David Howland & Team | CHDI largely funded the generation of both acute and transgenic minipig model of Huntington´s disease. David Howland, PhD., and his team help us with their experience gained in collaboration with the teams which generated other large animal models of HD, especially sheep, small primates and mice. CHDI continues with financial and scientific support of the phenotypic characterization of our transgenic pig model of HD. | |
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Czech Huntington´s Association | Zdenka Vondrackova, Jiri Hruda & Team |
Zdenka Vondrackova, Dr., and Jiri Hruda, Dr., regularly organize the meetings of HD patients and their families. The opportunity to attend these meetings motivates us tremendously in our research work. We have lectures about the news in HD research for Czech Huntington´s community. Moreover, we also write articles about HD scientific news in plain language in the CHDA´s Bulletin Archa. | |
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George Huntington’s Institut, Muenster | Ralf Reilmann & Team | Ralf Reilmann, MD., PhD., has vast experience in characterization of the progress of Huntington's disease (TRACK-HD), which also enabled the characterization of motor and cognitive functions in our transgenic pig model pf HD. Ralf and his team work on development of a method for assessing the disease in large animals, which then can be applied to the porcine model. In addition, the study includes MRI of the pig´s brains. | |
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Massachusetts General Hospital, Department of Neurology | Marian DiFiglia & Team | Marian´s DiFiglia, Prof., PhD., experiences and practices with immunohistochemical and histological characterization of the brains of HD patients and HD mice models are reflected in our results obtained in study of the brains of the pig model of HD. | |
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MediTox | Ivana Surova, Lukas Recek & Team | The project was focused on the development and optimization of the pig model of traumatic spinal cord injury and model of Huntington´s disease which could enable testing of the new therapeutic approaches. | |
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Neuralstem Inc. | |||
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Oslo University Hospital, Department of Medical Biochemistry, Mitogroup | Lars Eide & Team | ||
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Oslo University Hospital | Arne Klungland & Team | Cooperation with the Arne Klungland, Prof., PhD., and his team helps us determine the number of glutamines in mutated polyQ repetition and determine the stability of the repetition in various porcine tissues. | |
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uniQure | |||
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University of Milan, Department of Biosciences | Elena Cattaneo, Marta Valenza & Team |
Collaboration with Elena Cattaneo, Prof., PhD., and Marta Valenza, PhD., reveals the secrets of cholesterol biosynthesis in transgenic pig model of HD. | |
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University of San Diego, Department of Anestesiology | Martin Marsala & Team | Prof. Martin Marsala, MD, PhD., And his team are actively involved in generation of a porcine model of traumatic spinal cord injury. In cooperation with Martin and Neuralstem, Inc., we also implant human stem cells to the damaged spinal cords. |
