MŠMT
MŠMT
The program is multi-annual thematic program under the auspices of the Ministry of Education, Youth and Sport, within which i tis possible to draw funds from the European Structural and Investment funds (ESIF).
OP VVV
Operation program research, development and education 
Supporting the mobility of researches in the Framework in the internationl cooperation.
The program is focused on supporting the initiation and further development of international research cooperation and the development and integration of the Czech Republic into European and world research structures
INTER-EXCELLENCE
INTER-ACTION
International cooperation in research and development.
Basic information: The life of the vast majority of today's eukaryotic organisms depends on atmospheric oxygen, which reached its current level about 450 million years ago. Oxygen serves in the mitochondria to effectively fix energy from carbohydrates and other substrates. However, the products of oxygen metabolism such as hydrogen peroxide are toxic to cells and therefore various redox reactions take place in specialized organelles, peroxisomes. There is a close interplay between mitochondria and peroxisomes, although their evolutionary origin and biogenesis are different. A typical peroxisomal metabolic pathway is beta-oxidation of fatty acids, with most peroxisomal enzymes being of mitochondrial evolutionary origin. In some organisms, this pathway is in both organelles, while e.g. in yeast, it is only in peroxisomes and mitochondria use peroxisomal beta-oxidation products. In addition, mitochondria are directly involved in the biogenesis of peroxisomes.
Registration No: LUAUS23052
Project Duration: 1. 3. 2023 – 31. 12. 2026
Principal Investigator: Profesor RNDr. Jan Tachezy, Ph.D. Charles University, Faculty of Science
Other solver: RNDr. Kateřina Olša Fliegerová CSc. Institute of Animal Physiology and Genetics CAS, v. v. i.
Basic information: Research regarding formation and homeostasis of cartilage is an attractive topic for basic as well as clinically oriented research. Chondrogenesis is associated not only with cartilage itself (e. g. joint cartilage) but also growth plates of the long bones (endochondral ossification). Cartilage, besides bone, belongs to the key structures for body support and movement. Disbalance in articular cartilage homeostasis may result in painful degenerative joint diseases such as osteoarthritis (OA). Recent molecular and cellular research into physiological principles of cartilage biology yields data, which are often a source for pathophysiological investigations and outcomes for novel regenerative treatment strategies. Prevention and treatment of OA are one of the aims in agreement with the European concept of “life-long health” due to increasing elderly population and support of high life quality including the older age. Caspases are cysteine proteases well-known from apoptotic and inflammatory processes, however, they display a much broader spectrum of functions which are in focus of recent research. The Czech project team performed a screening investigation showing the effect of general caspase inhibition on expression of OA-related genes in healthy chondrocytes. However, the impact of individual caspases and underlying mechanisms need yet to be specified. Caspase-1 is a hot candidate regarding osteoarthritis. The bilateral project will benefit from the research synergy of both teams and their most recent results to provide data contributing to understanding molecular mechanisms of the caspase-1 inhibitory effect in chondrocytes with focus on both, healthy and OA-like chondrocytes (in mouse and human models) and on caspase-1 inhibitors considered for clinical applications: VX-740 (Pralnacasan) and VX-765 (Belnacasan).
Registration No: LUABA22019
Project Duration: 1. 7. 2022 – 31. 12. 2024
Investigator: prof. RNDr. Eva Matalová, Ph.D. Institute of Animal Physiology and Genetics CAS, v. v. i.
INTER-COST
The international cooperation in research and development
