MZ CŘ
MZ CŘ
Individual projects of the Ministry of helth are provided of the Agency for Health Reaserch of the Czech Republic (AZV ČR), which provides targeted support in accordance with the National Policy of Research, Experimental development and Innovation of the Czech Republic.
Prognostic and predictive markers of squamous cell carcinoma invasion in the oral cavity and oropharynx
Basic information: Carcinomas of the oral cavity and oropharynx belong among the ten most common malignancies in human population. In this project, we will focus on the most common squamous cell carcinoma. The prognosis of these malignancies is determined by the degree of invasiveness of the primary tumor and by the extent of metastatic spread into regional and distant lymph nodes. The intensity of perineural invasion correlates with tumor localization, its extent, and the presence of nodal metastases. In our project, we will focus on the detection of clinically relevant somatic mutations in patients with perineural invasion and the evaluation of early molecular markers during perineural invasion, which are expressed on the interface between tumor and surrounding tissues. Moreover, we will analyze role of primary cilia and Sonic hedgehog pathway in tumorous cells and the effect of altered SHH signaling on perineural invasion. Our aim is to introduce new protocols into routine histopathological diagnostics aiming to predict future cell behavior, which will improve planning and management of the subsequent therapies in patients.
Registrtion No: NU19-08-00383
Project duration: 1. 5. 2019 – 31. 12. 2022
Principal Investigator: doc. RNDr. Marcela Buchtová, Ph.D. Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
Other solver: MUDr. et MUDr. Jan Štembírek, Ph.D. Fakultní nemocnice Ostrava
New minimally invasive techniques for treatment of postoperative Crohn’s disease recurrence on experimental model
Basic information: Most of the patients operated for Crohn's disease develop recurrence in ileocolic anastomosis. Medical treatment is usually ineffective in these cases and patients require re-operation. New endoscopic techniques could delay or completely avoid the need for re-resection and thereby can improve patients’ quality of life and reduce the costs. Expected outcome of the project is the experimental evaluation of new minimally invasive treatment techniques of Crohn's disease recurrence including the design of therapeutic algorithm. A unique model of anastomotic stricture will be developed during this project and will be available for other studies. This project supports optimization of treatment based on models, use of new minimally invasive techniques with the aim to reduce potential complications and promote multidisciplinary cooperation of surgeons and gastroenterologists.
Registrtion No: NU19-08-00449
Project duration: 1. 5. 2019 – 31. 12. 2022
Principal Investigator: MUDr. Ondřej Ryska, Ph.D. Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
Other solver: MUDr. Jaroslav Kalvach Ústřední vojenská nemocnice - Vojenská fakultní nemocnice Praha
The interplay between the gut microbiota and brain functions: implication for metabolome and metabolic syndrome in schizophrenia
Basic information: Schizophrenia (SCZ) is a serious mental disease with high morbidity. The modern antipsychotics are effective in its therapy, but they may induce obesity and metabolic syndrome. Alteration in metabolism, changes in gut microbiota, gut barrier failure and low-grade chronic inflammation are all involved in pathogenesis of both SCZ and metabolic syndrome. Therefore, by analysis of microbiome, metabolome, gut barrier function and inflammatory response, new biomarkers for prediction of this serious therapy side-effect may be found. Moreover, by analyzing the key mechanisms in the pathogenesis of both conditions, this approach may even uncover suitable target for future therapy of SCZ or metabolic syndrome. We will use samples of blood, stool or urine, collected from patients with SCZ at the beginning of the antipsychotic treatment and after several months, when the presence or absence of the metabolic syndrome will be clearly apparent. Few animal experiments will be performed to identify the best possible targets before these will be used in full-scale investigation on humans.
Registrtion No: 17-31852A
Project duration: 1. 4. 2017 – 31. 12. 2021, extended to 30. 6. 2022
Principal Investigator: MUDr. Tomáš Páleníček, Ph.D. Národní ústav duševního zdraví
Other solver: RNDr. Kateřina Olša Fliegerová, CSc. Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
New minimally invasive techniques for treatment of postoperative Crohn’s disease recurrence on experimental model
Basic information: Most of the patients operated for Crohn's disease develop recurrence in ileocolic anastomosis. Medical treatment is usually ineffective in these cases and patients require re-operation. New endoscopic techniques could delay or completely avoid the need for re-resection and thereby can improve patients’ quality of life and reduce the costs. Expected outcome of the project is the experimental evaluation of new minimally invasive treatment techniques of Crohn's disease recurrence including the design of therapeutic algorithm. A unique model of anastomotic stricture will be developed during this project and will be available for other studies. This project supports optimization of treatment based on models, use of new minimally invasive techniques with the aim to reduce potential complications and promote multidisciplinary cooperation of surgeons and gastroenterologists.
Registrtion No: NU18-04-00455
Project duration: 1. 5. 2018 – 31. 12. 2021
Principal Investigator: prof. RNDr. Omar Šerý, Ph.D. Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
Other solver: prof. doc. MUDr. Jakub Hort, Ph.D. Fakultní nemocnice u sv. Anny v Brně
Basic information: Ontogenesis and tumorigenesis often share regulatory molecules that modulate key cellular events including cell proliferation, differentiation and survival. The c-Myb protein has been associated with control of these processes. Aberrant activation of c-Myb disturbs the balance in favor of proliferation and survival, thus contributing to malignant transformation. Our earlier research showed that c-Myb is involved in regulation of embryonal bone development. Recent findings, including preliminary data presented by us, demonstrate that c-Myb is expressed in osteosarcomas, bone tumors with specific age-related incidence. The aim of this study is to clarify the function of c-Myb in different stages of physiological bone development, and most importantly, the relevance of c-Myb in control of osteosarcoma progression and chemoresistance using cell lines, in vivo models and a clinical study. The clinical part will be further extended to other osteogenic pathologies with high incidence in childhood to further assess the importance of c-Myb in bone homeostasis in humans.
Registrtion No: NU18-07-00073
Project duration: 1. 5. 2018 – 31. 12. 2021
Principal Investigator: doc. Mgr. Petr Beneš, Ph.D. Masarykova univerzita, Přírodovědecká fakulta
Other solver: MUDr. Peter Múdry, Ph.D. Fakultní nemocnice Brno
Other solver: MUDr. Dagmar Adámková Krákorová, Ph.D. Masarykův onkologický ústav
Other solver: prof. RNDr. Eva Matalová, Ph.D. Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
