TA ČR
TA ČR
Basic information: The goal of the project is, through industrial research and experimental development, to develop a proven technology for the production of medicinal substances in the correct laboratory quality (SLK) for the treatment of malignant tumors, which will work on the principle of MBTA - non-cellular tumor immunotherapy. The sales item that will be created through the research and development of proven technology will be a unique combination of substances for the MBTA therapy method - that is, a method that applies a combination of developed substances directly to tumors for the purpose of treatment. This is an intermediate step on the way to the development of a medicinal product, for which preclinical and clinical evaluation and registration by state authorities will at the end of project.
Registration No: FW12010389
Project Duration: 1. 1. 2025 – 31. 12. 2027
Principal investigator: Mgr. David Větvička, Ph.D. Bioinova, s.r.o.
Other solver: Mgr. Helena Kupcová Skalníková, Ph.D. Institute of Animal Physiology and Genetics CAS, v. v. i.
Other solver: RNDr. Luděk Šefc, CSc. First faculty of Medicine Charles University
Genetic diversity of the weather loach (Misgurnus fossilis) in the Czech Republic – providing fundamental data for conservation measures of a disappearing, critically endangered species
Basic information: The project aims to evaluate the genetic diversity of the unexplored but critically endangered fish, the weather loach. Regular removal of muddy sediments in habitats accompanies the species´ rescue transfers despite a lack of knowledge of its biology and population sizes. We will establish procedures for effective population size estimates and to minimize the number of individuals not caught before technological intervention in the habitat. We develop a reproducible methodological procedure for evaluating individuals´ genetic diversity, origin and ploidy and pilot-test it at 30 localities across Czech watersheds. Practical application of the methodology will prevent unwanted mixing of reproductively and by-origin incompatible populations and different-ploidy individuals during transfers.
Registration No: SS07010366
Project Duration: 1. 4. 2024 – 31. 12. 2026
Principal investigator: RNDr. Lukáš Choleva, Ph.D. Institute of Animal Physiology and Genetics CAS, v. v. i.
