Basic information: The miniature pig shares many anatomical and physiological similarities with humans, making it a viable alternative to non-human primates in non-clinical safety studies. The EU-funded NHPig project aims to enhance the use of mini- and micropig models for such studies. The project will characterise humanised minipigs and micropigs, focusing on biobanking, multi-omics profiling and advanced imaging techniques. It will also develop biosensors and automated systems for data collection and analysis in safety studies, address knowledge gaps in porcine immunology, validate biomarkers for toxicity and efficacy, tackle the shortage of laboratory tools and develop porcine in vitro models as non-animal alternatives. The project adheres to the 3Rs principles and will ensure compliance with ethical standards.

Registration No: 101165643

Project duration: 1. 10. 2024 – 30. 9. 2029

Principal Investigator: Ludwig-Maximilians-Univerzita Mnichov

Other solver: Ing. Zdenka Ellederová, Ph.D., Institute of Animal Physiology and Genetics CAS, v. v. i.

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