TA ČR
TA ČR
Development of standardized culture, transplantation and banking of RPE cells for treatment of age-related macular degeneration (AMD)
Basic information:
The project aims to develop a standardized, safe and efficient method for curing dry age-related macular degeneration (AMD) - the most frequent cause of visual impairment that currently lacks treatment. The work will bring promising retina pigment epithelial (RPE) cell research to a clinical trial using patient-derived stem cell therapy. The Specific aims are focused at: 1) isolation, cultivation and optimization of human RPE cells, primary hRPEs and induced pluripotent stem cell (iPSC)-derived RPEs; 2) preparation of nanofibrous scaffold; 3) transplantation of hRPE-covered scaffolds in the subretinal space; 4) non-invasive (OCT, mfERG) and end-stage cell and tissue characterization (IHC, tEM); 5) establishment of good manufacturing practice (GMP) protocols and clinical-grade cell banking.
Registration No: TO01000107
Project Duration: 1. 1. 2021 – 30. 4. 2024
Principal investigator: prof. MVDr. Jan Motlík, DrSc. Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
Other solver: MUDr. Miroslav Veith Fakultní nemocnice Královské Vinohrady
Other solver: Professor Goran Petrovski, MD, Ph.D., Dr. habil. University of Oslo, Center for Eye Research
Other solver: Ing. Hana Studenovská, Ph.D. Ústav makromolekulární chemie AV ČR, v. v. i.
Basic information: The aim of the project is to develop a system and protocol for measurement and analysis of pig gait. The system will consists of a set of inertial measurement units and newly created software for processing and analysis of measured pigs signals. The SW will outputs a range of gait parameters. The purpose is to provide a comprehensive product for the analysis of pig gait for research and commercial organizations. This tool will be easy to use, with a graphical user interface for displaying measured signals and data export. Target organizations will be able to use a commercially available product instead of creating their own gait analysis tools before the research. As a result, this will reduce study costs. System development will be finished before end of the project.
Registration No: TJ02000092
Project Duration: 1. 3. 2019 – 28. 2. 2021
Principal investigator: Ing. Tereza Duspivová Czech Technical University in Prague, Fakulty of Biomedical Engineering
Other solver: Ing. Zdenka Ellederová, Ph.D. Institute of Animal Physiology and Genetics CAS, v. v. i.
