Eva Nagyova, DVM, Ph.D., DSc.

Personal information

/Research Professor/
Nationality: Czech/Slovak

Education

2016 DSc./Research Professor Thesis: Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
Cellular and molecular events associated with oocyte maturation in ovarian follicles
1985-1990 Ph.D. Thesis: Institute of Animal Physiology and Genetics, Prague, Academy of Sciences of the Czech Republic;
Concentration of cAMP during oocyte maturation in mammals.
1985 1st Postgraduate Medical Specialization
1981 Animal husbandry in particular animal health (checking meat factories and also food technology process (pork, beef, and poultry).
1976-1981 D.V.M. Doctor of Veter. Medicine; Veterinary University Kosice, Slovakia

Previous and current position

Since 2004 Senior scientist; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
1993-2003 Staff scientist; Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
1989-1992 Scientist, Reproductive Endocrinology, Research Institute of Animal Production, Prague, Czech Republic

Fellowships and awards

2013-2013 OECD Fellowship Award, Department of Public Health and Cell Biology, Faculty of Medicine, University of Rome, Italy (3 months)
Synthesis of matrix components in ovarian follicle.
Collaboration with Prof. Salustri A and Camaioni A
2012-2014 Priority Research Collaboration between SAS and ASCR (N.18)
Steroid hormones in ovarian follicle (3x 1 month)
Collaboration with Dr. Scsukova S, and Dr. Bujnakova – Mlynarcikova A
2002-2007 Program of Scientific and Technological Co-operation between the Government of the Italian Republic and the Government of the Czech Republic;
Visiting Scientist (6 x 3 months)
Cumulus expansion associated proteins.
2002 OECD Fellowship Award, Department of Public Health and Cell Biology, Faculty of
Medicine, University of Rome, Italy
Hyaluronan in ovarian follicle (6 months)
1997 OECD Fellowship Award, Cancer Research Center, Ottawa, Canada -Oocyte secreted factors (6 months);
Collaboration with Prof Vanderhyden BC
1994 INSERM, Paris-Clamart, France - Oocyte competence and calcium signaling in mice (Carta Orange, 3 months)
1992 Norwegian College of Veterinary Medicine, Oslo, Norway –Oocyte maturation in cow and fox (3 months)

Memberships of scientific societies

Since 2012 Member of the “Society for Reproduction and Fertility “
Since 2000 Member of “European Society of Human Reproduction and Embryology”
Since 1997 Member of the “Society for Study of Reproduction”

Grants and projects

2011-2014 GA CR P502/11/0593
2012-2014 Priority Research Collaboration between Slovak Academy of Sciences and Academy of Sciences of the Czech Republic
2011-2012 Cancer research activity: Project supported by GlaxoSmithKline, s.r.o. Czech Republic /Nagyova et al. 2013 Fert Ster.
2008-2011 GA CR 523/08/0111
2003-2007 Grant 52/ZV2 from Ministry of School, Youth and Education; Program of Scientific and Technological Co-operation /Italy- Czech Republic
2005-2007 Grant Agency of the Czech Republic –305/05/0960
2001-2003 Grant Agency AV–A5045102/01
2001 GA CR- 504 5102/01
1998 GA CR - 524/98/0231
1994-1996 Grant Agency AV–A745 401

International major collaboration

  • Department of Public Health and Cell Biology, Faculty of Medicine, University of Rome, Italy
    Collaboration with Prof. Camaioni A; in the field of Reproductive Biology
  • Priority Research Collaboration with Dr. Scsukova S and Dr. Bujnakova Mlynarcikova A; Institute of Experimental Endocrinology, Bratislava, Slovakia; in the field of Ovarian Endocrinology
  • Matrix Biology, with Prof. Day AJ; Division of Cell Matrix Biology, School of Biological Sciences, and University of Manchester, UK

Reviewing activities

2003 Member of the Expert Group of EC /: Debating bioethical issues: Budapest
2003-2004 Evaluator of EC/Individual Assessment Report in 2003;
Panel evaluation process in Brussel in 2004
2006, 2008 Evaluator of Projects for “Cooperative Research Networks Ministry of Health and Consumer's Affairs”, Instituto de Salud Carlos III, Sinesio Delgado, 6, Madrid
2014, 2018 2x Evaluator for APVV project in Slovakia
2015 “The Certificate of Peer Review Expert” from Slovak Research and Development Agency

Regular manuscript reviews

Biology of Reproduction; Reproduction; Molecular Reproduction Development; Animal Reproduction Science; Domestic Animal Endocrinology; Zygote; Human Reproduction; Fertility and Sterility

Language skills

English, French, Italian

Scientific record and achievement of the proposer:

Selection of publications (main author) in peer-reviewed journals

  • H index: 20; Total citations: 954: Average citation per article: 17 /WoS data: 24.8.2019/
  • 48 publications in peer-review journals, including 4 reviews as the sole author and 16 as the first author

 

  1. Cumulus Extracellular Matrix Is an Important Part of Oocyte Microenvironment in Ovarian Follicles: Its Remodeling and Proteolytic Degradation. Review. Eva Nagyová *, Lucie Nemcová and Antonella Camaioni. Int. J. Mol. Sci. 2022, 23(1), 54; https://doi.org/10.3390/ijms23010054 - 21 Dec 2021
  2. Nagyova E, Salustri A, Nemcova L, Scsukova S, Kalous J, Camaioni A. Versican G1 fragment establish a strongly stabilized interaction with hyaluonan-rich expanding matrix during oocyte maturation. Int J Mol Sci. 2020 Mar 25;21(7):2267. doi: 10.3390/ijms21072267.
  3. Nagyova E. The Biological Role of Hyaluronan-Rich Oocyte-Cumulus Extracellular Matrix in Female Reproduction. Int J Mol Sci 2018; 18; 19(1). doi: 10.3390/ijms19010283. Review Times Cited 4x
  4. Nagyova E, Nemcova L, Bujnakova Mlynarcikova A, Blaha M, Prochazka R, Scsukova S. Effect of bone morphogenetic protein-15 on gonadotropin-stimulated synthesis of hyaluronan and progesterone in porcine ovarian follicle. J Physiol Pharmacol 2017; 68(5):683-691 . Times Cited 4x
  5. Nagyova E, Kalous J, Nemcova L. Increased expression of pentraxin 3 after in vivo and in vitro stimulation with gonadotropins in porcine oocyte-cumulus complexes and granulosa cells. Domest Anim Endocrinol 2016l; 56:29-35. doi: 10.1016/j.domaniend.2016.01.004. Times Cited 1x
  6. Nagyova E. Organization of the expanded cumulus-extracellular matrix in preovulatory follicles: a role for inter-alpha-trypsin inhibitor. Endocr Regul 2015; 49(1):37-45. doi: 10.4149/endo_2015_01_37. Review Times Cited 8x
  7. Nagyova E, Scsukova S, Kalous J, Mlynarcikova A. Effects of RU486 and indomethacin on meiotic maturation, formation of extracellular matrix, and progesterone production by porcine oocyte-cumulus complexes. Domest Anim Endocrinol 2014; 48:7-14. doi: 10.1016/j.domaniend.2014.01.003. Times Cited 5x
  8. Nagyova E, Nemcova L, Mlynarcikova A, Scsukova S, Kalous J. Lapatinib inhibits meiotic maturation of porcine oocyte-cumulus complexes cultured in vitro in gonadotropin-supplemented medium. Fertil Steril 2013; 99(6):1739-48. doi: 10.1016/j.fertnstert.2012.12.040. Times Cited 3x
  9. Nagyova E. Regulation of cumulus expansion and hyaluronan synthesis in porcine oocyte-cumulus complexes during in vitro maturation. Endocr Regul 2012; 46(4):225-35.doi:10.4149/endo_2012_04_225. Review Times Cited 20x
  10. Nagyova E, Scsukova S, Nemcova L, Mlynarcikova A, Yi YJ, Sutovsky M, Sutovsky P. Inhibition of proteasomal proteolysis affects expression of extracellular matrix components and steroidogenesis in porcine oocyte-cumulus complexes. Domest Anim Endocrinol 2012;42(1):50-62. doi: 10.1016/j.domaniend.2011.09.003. Times Cited15x
  11. Nagyova E, Camaioni A, Scsukova S, Mlynarcikova A, Prochazka R, Nemcova L, Salustri A. Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis. Mol Reprod Dev 2011; 78(6):391-402. doi: 10.1002/mrd.21312. Times Cited19x
  12. Nagyova E, Nemcova L, Prochazka R. Expression of tumor necrosis factor alpha-induced protein 6 messenger RNA in porcine preovulatory ovarian follicles. J Reprod Dev. 2009;55(3):231-5. doi: 10.1262/jrd.20115. Times Cited 17x
  13. Nagyova E, Camaioni A, Prochazka R, Day AJ, Salustri A. Synthesis of tumor necrosis factor alpha-induced protein 6 in porcine preovulatory follicles: a study with A38 antibody. Biol Reprod 2008;78(5):903-9. doi: 10.1095/biolreprod.107.064832. Times Cited 13x
  14. Nagyova E, Camaioni A, Prochazka R, Salustri A. Covalent transfer of heavy chains of inter-alpha-trypsin inhibitor family proteins to hyaluronan in in vivo and in vitro expanded porcine oocyte-cumulus complexes. Biol Reprod 2004;71(6):1838-43. doi: 10.1095/biolreprod.104.029595. Times Cited 37x
  15. Nagyova E, Vanderhyden BC, Prochazka R. Secretion of paracrine factors enabling expansion of cumulus cells is developmentally regulated in pig oocytes. Biol Reprod 2000;63(4):1149-56. doi: 10.1095/biolreprod63.4.1149. Times Cited 32x
  16. Nagyova E, Prochazka R, Vanderhyden BC. Oocytectomy does not influence synthesis of hyaluronic acid by pig cumulus cells: retention of hyaluronic acid after insulin-like growth factor-I treatment in serum-free medium. Biol Reprod 1999; 61(3):569-74. doi: 10.1095/biolreprod61.3.569. Times Cited 35x

Invited conferences and presentations:

  1. Proper structure of oocyte-cumulus extracellular matrix depends on the interaction between hyaluronan and inter-alpha-trypsin inhibitor in ovarian follicles. By: Nagyova E, Vodicka P. Fertility Conference, 9-11 January, 2020 EICC Edinburgh, UK
  2. Effect oocyte factors on granulosa cells differentiation and cumulus- extracellular matrix organization. By: Nagyova et al.  Fertility Conference, January 2019; ICC Birmingham, UK;
  3. Cumulus extracellular matrix represents an important new mechanism in the regulation of ovulatory process in porcine follicles. By: Nagyova Eva.  Fourth World Congress of Reproductive Biology 2017; Okinawa, Japan
  4. Effect of bone morphogenetic proetin15 (BMP15) on gonadotropin –stimulated synthesis of hyaluronan and progesterone in ovarian follicle By: Nagyova Eva, Fertility 2017 Meeting; Edinburg, UK
  5. Gonadotropins induce expression of versican in porcine oocyte–cumulus extracellular matrix and mural granulosa cells. By: Nagyova et al.  SRF Annual Conference, University of Winchester, Winchester, UK, 11-13 July, 2016
  6. Lapatinib inhibits meiotic maturation of porcine oocyte-cumulus complexes cultured in vitro in gonadotropin-supplemented medium By: Nagyova et al. Scientific Conference on Endocrine Disruptors; Bratislava, Slovakia, 16-17, 2012
  7. Involvement of EGFR and Smad2/3 Activation in FSH-Induced Porcine Oocytes-Cumulus Cell Complex Maturation By: Nagyova et al. Conference: 43rd Annual Meeting of the Society-for-the-Study-of-Reproduction; Milwaukee, WI; JUL 31-AUG 03, 2010; BIOL REPROD Suppl: 
  8. Altered organization of the oocyte-cumulus extracellular matrix in the presence of proteasomal inhibitor MG132 By: Nagyova et al. Conference: Joint Conference of the 33rd FEBS Congress/11th IUBMB Conference; Athens, GREECE; JUN 28-JUL 03, 2008. FEBS JOURNAL Suppl: 261
  9. Proteasomal activity is involved in oocyte meiosis and cumulus expansion during in vitro maturation of porcine oocytes.By: Yi, Young-Joo; Nagyova et al. Conference: 39th Annual Meeting of the Society-for-the-Study-of-Reproduction: Univ Nebraska Med Ctr, Omaha, NE; JUL 29-AUG 01, 2006. BIOL REPROD Special Issue:  177
  10. Synthesis of tumor necrosis factor-stimulated gene-6 protein by cumulus and granulosa cells in porcine preovulatory follicle. By: Nagyova et al. Conference: 38th Annual Meeting of the Society-for-the-Study-of-Reproduction; Quebec City, CANADA; JUL 24-27, 2005. BIOL REPROD Special Issue: SI; 159
  11. Covalent transfer of inter-alpha-trypsin inhibitor heavy chains to hyaluronan in porcine oocyte-cumulus complexes cultured in vitro. By: Nagyova et al. Conference: 36th Annual Meeting of the Society-for-the-Study-of-Reproduction; CINCINNATI, OHIO; JUL 19-22, 2003 BIOL REPROD;   
  12. Evaluation of members of the TGF beta superfamily as candidates for the oocyte factors that control mouse cumulus expansion and steroidogenesis. By: Vanderhyden, BC; Macdonald, EA; Nagyova, E; Conference: 6th International Symposium on Reproduction; CRIEFF, SCOTLAND AUG 14-17, 2002. REPRODUCTION Suppl: 61; 55-70
  13. Effect of porcine oocytes at different stages of development on synthesis of hyaluronic acid by mouse oocytectomized complexes By: Nagyova, E et al. Conference: Proceedings of the Annual Conference of the International Embryo Transfer Society Location: Maastricht, Netherlands Date: January 09-11, 2000. Theriogenology 53 Issues:  462
  14. Porcine oocytes produce CEEF only during their growth period and transition to metaphase I. By: Nagyova et al. J. Annual Conference of the International Embryo Transfer Society Location: Nice, France Date: January 12-14, 1997.Theriogenology Volume: 47   Issue: 1   Pages: 197