Mgr. Jakub Červenka

Education

2015-now Ph.D. student, Developmental and Cell Biology, Faculty of Science, Charles University
2012-2015 MSc. student, Genetics, Molecular Biology and Virology, Faculty of Science, Charles University

Professional experience

2015-now Ph.D. student in Laboratory of applied proteome analyses

Major scientific interests

  • Characterisation of human neural stem cells differentiation in vitro employing techniques of untargeted (shotgun) and targeted (SRM/MRM a SWATH-MS) mass spectrometry, as well as qRT-PCR and flow cytometry. Part of the project is focused on development of specific and fast assay to simultaneously probe cellular processes during neural development using SRM/MRM approach.
  • Analyses of human neural stem cells secretome during in vitro neuronal differentiation usingLuminex xMap technology.
  • Proteomics of extracellular vesicles isolated from body fluids (blood plasma, cerebrospinal fluid and seminal plasma).
  • Characterization of Liběchov's transgenic minipig model of Huntington's disease.

Grants

2017-2019 Charles University Grant Agency – project No. 1460217: Identification and quantification of candidate brain-specific biomarkers of neurodegeneration during Huntingtonˈs disease development. Co-researcher.
2018-2019 Charles University Grant Agency – project No. 1767518: Characterization of growth factor directed in vitro neuronal differentiation of human neural stem cells. Principal researcher.

Membership in academic councils and editorial boards

2019-now Czech society for biochemistry and molecular biology (ČSBMB, z. s)

Publications

Researchgate

ORCID