MUDr. Taras Ardan, Ph.D.

Education

1994 M.D., 1st Faculty of Medicine, Charles University, Prague, CZ
2005 Ph.D., 1st Faculty of Medicine, Charles University, Prague, CZ
2013 Supervisor of Doctoral Study Program in Biomedicine “Biology and Pathology of the Cell”, 1st Faculty of Medicine, Charles University, Prague, CZ
2015 Supervisor of Doctoral Study Program in Biomedicine “Developmental and Cell Biology”, Faculty of Science, Charles University, Prague, CZ

 

Professional experience

1998-2012 Institute of Experimental Medicine CAS, Department of Eye Histochemistry and Pharmacology, Prague, CZ
2004-2005 Research Worker
2005 Scientific Worker
2013-now Scientific Worker, Institute of Animal Physiology and Genetics CAS Department of Cell Regeneration and Plasticity, Libechov, CZ

 

Membership in academic councils and editorial boards

  ARVO (The Association for Research in Vision and Ophthalmology)
  EVER (European Association for Vision and Eye Research)
  TFOS (Tear Film and Ocular Surface Society)
2013 Member of the Editorial Board of Journal of Ophthalmology (IF 1.463)

 

Total number of citations

  • 351

Total number of papers in impacted journals

  • 22

H-Index

  • 10

 

Major scientific interests

  • The experimental eye research (cornea, lens, retina) in normal and disease states at the cellular and molecular level, development of new therapy approaches for the treatment of damaged cornea and retina (cellular therapy, nanofibrous cellular implants). Huntington's disease research on the transgenic animal models.

 

Research fellowships and study visits

2004 Department of Ophthalmology, University of Tampere, Tampere, Finland – cell therapy of the cornea

 

Grants

2010-2012 Principal investigator: Matrix metaloproteinázy v závažně poškozené rohovce a po její rekonstrukci transplantací kmenových buněk. Grant Agency of CZ. P302/10/P155

 

Publications

2016 Ardan T, Němcová L, Bohuslavová B, Klezlová A, Popelka Š, Studenovská H, Hrnčiarová E, Čejková J, Motlík J. (2016). Reduced Levels of Tissue Inhibitors of Metalloproteinases in UVB-Irradiated Corneal Epithelium. Photochem Photobiol. 92(5):720-7
2015 Popelka Š, Studenovská H, Abelová L, Ardan T, Studený P, Straňák Z, Klíma J, Dvořánková B, Kotek J, Hodan J, Rypáček F. (2015). A frame-supported ultrathin electrospun polymer membrane for transplantation of retinal pigment epithelial cells. Biomed Mater. 10(4)
2012 Ardan T, Čejková J (2012). Immunohistochemical expression of matrix metalloproteinases in the rabbit corneal epithelium upon UVA and UVB irradiation. Acta Histochem. 114: 540-6.
2011 Čejka, Č., Ardan, T., Sirc, J., Michálek, J., Beneš, J., Brůnová, B., Rosina, J. (2011) Hydration and transparency of the rabbit cornea irradiated with UVB-doses of 0.25 J/cm(2) and 0.5 J/cm(2) compared with equivalent UVB radiation exposure reaching the human cornea from sunlight. Curr. Eye Res. 36(7): 607-613.
  Čejková, J., Ardan, T., Čejka, Č., Luyckx, J. (2011) Favorable effects of trehalose on the development of UVB-mediated antioxidant/pro-oxidant imbalance in the corneal epithelium, proinflammatory cytokine and matrix metalloproteinase induction, and heat shock protein 70 expression. Graefes Arch. Clin. Exp. Ophthalmol. 249(8): 1185-1194.
2010 Čejka, Č., Pláteník, J., Širc, J., Ardan, T., Michálek, J., Brůnová, B., Čejková, J. (2010) Changes of corneal optical properties after UVB irradiation investigated spectrophotometrically. Physiol. Res. 59(4): 591-597.
  Čejka, Č., Luyckx, J., Ardan T., Pláteník, J., Širc, J., Michálek, J., Čejková, J. (2010) The Effect of Actinoquinol with Hyaluronic Acid in Eye Drops on the Optical Properties and Oxidative Damage of the Rabbit Cornea Irradiated with UVB Rays. Photochem. Photobiol. 86(6): 1294-1306.
  Čejka, Č., Ardan, T., Širc, J., Michálek, J., Brůnová, B., Čejková, J. (2010) The influence of various toxic effects on the cornea and changes in corneal light transmission. Graefes Arch Clin Exp Ophthalmol. 248(12): 1749-56.
  Čejková, J., Čejka, Č., Ardan, T., Širc, J., Michálek, J., Luyckx, J. (2010) Reduced UVB-induced corneal damage caused by reactive oxygen and nitrogen species and decreased changes in corneal optics after trehalose treatment. Histol. Histopathol. 25(11): 1403-1416.
2009 Čejková J., Ardan T., Čejka Č., Malec J., Jirsová K., Filipec M., Růžičková E., Dotřelová D., Brůnová B. (2009). Ocular surface injuries in autoimmune dry eye. The severity of microscopical disturbances goes parallel with the severity of symptoms of dryness. Histol Histopathol. 24(10):1357-65.
  Čejka Č., Pláteník J., Buchal R., Guryca V., Širc J., Vejražka M., Crkovská J., Ardan T., Michálek J., Brůnová B., Čejková J. (2009). Effect of Two Different UVA Doses on the Rabbit Cornea and Lens. Photochem Photobiol. 85(3):794-800.
2008 Čejková J., Ardan T., Šimonová Z., Čejka Č., Malec J., Dotřelová D., Brůnová B. (2008). Decreased expression of antioxidant enzymes in the conjunctival epithelium of dry eye (Sjögren's syndrome) and its possible contribution to the development of ocular surface oxidative injuries. Histol Histopathol. 23(12): 1477-83.
2007 Čejková J., Ardan T., Šimonová Z., Čejka Č., Malec J., Jirsová K., Filipec M., Dotřelová D., Brůnová B. (2007). Nitric oxide synthase induction and cytotoxic nitrogen-related oxidant formation in conjunctival epithelium of dry eye (Sjögren's syndrome. Nitric Oxide 17(1): 10-7.
  Čejková J., Ardan T., Jirsová K., Jechová G., Malec J., Šimonová Z., Čejka Č., Filipec M., Dotřelová D., Brůnová B. (2007). The role of conjunctival epithelial cell xanthine oxidoreductase/xanthine oxidase in oxidative reactions on the ocular surface of dry eye patients with Sjögren's syndrome. Histol Histopathol 22(9): 997-1003.
  Kovačeva J., Pláteník J., Vejražka M., Štípek S., Ardan T., Čejka Č., Midelfart A., Čejková J. (2007). Differences in activities of antioxidant superoxide dismutase, glutathione peroxidase and prooxidant xanthine oxidoreductase/xanthine oxidase in the normal corneal epithelium of various mammals. Physiol Res 56(1): 105-12.
2005 Čejková J., Ardan T., Čejka Č., Kovačeva J, Zídek Z (2005). Irradiation of the rabbit cornea with UVB rays stimulates the expression of nitric oxide synthases-generated nitric oxide and formation of cytotoxic nitrogen-related oxidants. Histol Histopathol 20: 467-473.
2004 Ardan T., Kovačeva J., Čejková J. (2004). Comparative histochemical and immunohistochemical studies on xanthine oxidoreductase/xanthine oxidase in the corneal epithelium of various animals. Acta Histochemica 106: 69-75.
  Čejková J., Štípek S., Crkovská J., Ardan T., Pláteník J., Čejka Č., Midelfart A. (2004). UV rays, the prooxidant/antioxidant imbalance in the cornea and oxidative eye damage. Physiol Res 53: 1-10.
2002 Čejková J., Ardan T., Filipec M., Midelfart A. (2002). Xanthine oxidoreductase and xanthine oxidase in human cornea. Histol Histopathol 17: 755-760.
2001 Čejková J., Štípek S., Crkovská J., Ardan T., Midelfart A. (2001). Reactive oxygen species (ROS)-generating oxidases in the normal rabbit cornea and their involvement in the corneal damage evoked by UVB rays. Histol Histopathol 16: 523-533.
2000 Čejková J., Štípek S., Crkovská J., Ardan T. (2000) Changes of superoxide dismutase, catalase and glutathione peroxidase in the corneal epithelium after UVB rays. Histochemical and biochemical study. Histol Histopathol.15: 1043-1050.
1999 Čejková J., Zvárová,J., Andonova Ž, Ardan T. (1999) Comparative histochemical and biochemical studies on acid beta-galactosidase activity in the experimentally injured rabbit cornea and tear fluid using the sensitive substrate beta-galactoside-4-trifluoromethylumbelliferyl (HFC). Histol Histopathol 14: 471-478.