prof. RNDr. Marcela Buchtová, Ph.D.

Education

2010 Assoc. Prof. - University of Veterinary and Pharmaceutical Sciences Brno
Specialization: Normal and Pathological Morphology,
Habilitation thesis: Morphogenesis of craniofacial structures
2004 RNDr. - Faculty of Science, Masaryk University,
Specialty: Animal Physiology and Immunology.
Doctor’s thesis: Morphogenesis of palatal ridges
1997-2003 Ph.D. - University of Veterinary and Pharmaceutical Sciences Brno.
Specialization: Veterinary Morphology and Physiology;
Ph.D. thesis: Palatal structures during prenatal development
1992-1995 M.Sc. - Faculty of Science, Masaryk University,
Specialization: Animal Physiology
Master’s thesis: Development of skin appendixes during prenatal period in M. arvalis and T. europaea
1992-1995 Bc. - Faculty of Science, Masaryk University,
Specialization: General Biology

Research and Academic Positions:

since 2014 Associate Professor, Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno
since 2007 Researcher, head of LMM (from 2015), Vice-Director for Science (from 2022), Institute of Animal Physiology and Genetics, CAS
2007-2015 Assistant Professor and Associate Professor (from 2010), Department of Anatomy, Histology and Embryology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
2004-2007 post-doctorand, Department of Oral Health Sciences, University of British Columbia, Vancouver, Canada
2000-2004 lecturer, Department of Anatomy, Histology and Embryology, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic

International Training:

November 2013 Nanomédecine Régénérative Ostéoarticulaire et Dentaire, Faculte de Medicine (INSERM UMR 1109) Universite de Strasbourg, France
October 2012 Nanomédecine Régénérative Ostéoarticulaire et Dentaire, Faculte de Medicine (INSERM UMR 1109) Universite de Strasbourg, France
October 2011 Department of Craniofacial Development, and Department of Orthodontics, King´s College London Dental Institute, London, UK
July-August 2011 Department of Oral Health Sciences, University of British Columbia (Vancouver, Canada)
May 2011 Department of Craniofacial Development, and Department of Orthodontics, King´s College London Dental Institute, London, UK
July 2004 - August 2007 postdoctorant, Department of Oral Health Sciences, University of British Columbia (Vancouver, CA)
June 2004 Microarray Technology: Genome-Proteome Function, EMBO (Heidelberg, Germany)

Main Research Interests

  • molecular signaling during odontogenesis, tooth replacement and fate of progenitor cells in odontogenesis; identity of craniofacial prominences; causes of developmental defects in craniofacial area and during skeletogenesis; role of primary cilia in development; odontogenic tumors and cysts

Member of Scientific Councils

2017-up to now Academy Assembly of the Czech Academy of Sciences
2017-up to now Board of the Institute of Animal Physiology and Genetics
2011-2014

Academic Senate of the University of Veterinary and Pharmaceutical Sciences

- Scientific council of the PhD program Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, UVPS Brno
- Scientific council of the PhD program Stomatology, Faculty of medicine, Masaryk University, Brno
- Scientific council of the PhD program Animal Physiology, Faculty of Science, Masaryk University, Brno
- Scientific council of the PhD program Cell Biology and Pathology, First Faculty of Medicine, Charles University, Prague

Membership in Scientific Societies

  • Czech Anatomical Society (2008 - up to now, member of the Board of directors)
  • Society for Developmental Biology (2008 - up to now)
  • V4 Society for Developmental Biology (2018 – up to now, president, member of establishing committee)

Pedagogical Activities

2018 - up to now Physiology and Pathophysiology of Tissues and Organs, Masaryk University, Brno
2016 - up to now Embryology, Masaryk University, Brno, CR
2012-2015 Microscopic Anatomy of Vertebrates, University of Veterinary and Pharmaceutical Sciences Brno, CR
2011 - up to now Molecular Embryology, Masaryk University, Brno, CR
2009 - up to now Microscopic Anatomy of Vertebrates, Masaryk University, Brno, CR
2009-2015 Experimental Embryology, University of Veterinary and Pharmaceutical Sciences Brno, CR
2007-2015 Histology and Embryology, University of Veterinary and Pharmaceutical Sciences Brno, CR
2007-2009 Anatomy, University of Veterinary and Pharmaceutical Sciences Brno, CR
2000-2004 Histology and Embryology, University of Veterinary and Pharmaceutical Sciences Brno, CR
1998-2000 General Biology, Zoology, University of Veterinary and Pharmaceutical Sciences Brno, CR

Supervision of students

  • Ph.D. thesis (14; 8 theses successfully defended)
  • Master´s thesis (11; 8 theses successfully defended)
  • Bachelor’s thesis (15; 9 theses successfully defended)
  • Secondary school student project (SOČ) (12; 11 theses successfully defended; 4 of them proceeded to the National competition – 1st, 3rd place 2x and 8th place)

Summary of publication activity

  • Total number of publications with IF: 94 in WOS (37 during last 5 years)
  • Total number of publications without IF: 5 (3 during last 5 years)
  • Textbooks/online material for students: 6

Selected publications of last 6 years

  • Balek, L., Buchtova, M., Bosakova, M. K., Varecha, M., Foldynova-Trantirkova, S., Gudernova, I., Vesela, I., Havlik, J., Neburkova, J., Turner, S., Krzyscik, M. A., Zakrzewska, M., Klimaschewski, L., Claus, P., Trantirek, L., Cigler, P., Krejci, P. (2018): Nanodiamonds as "artificial proteins": Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals. Biomaterials, 176:106-121. (IF = 10.273)
  • Popa, E.M., Buchtová, M., Tucker, A.S. (2019): Revitalising the rudimentary replacement dentition in the mouse. Development, 8: 146(3) (IF = 5.763)
  • Nováková, M., Hampl, M., Vrábel, D., Procházka, J., Petrezsélyová, S., Procházková, M., Sedláček, R., Kavková, M., Zikmund, T., Kaiser, J., Juan, H.Ch., Fann, M.J., Buchtová, M., Kohoutek, J. (2019): Mouse model of congenital heart defects, dysmorphic facial features and intellectual developmental disorders as a result of nonfunctional CDK13. Frontiers in Cell and Developmental Biology, 7:155 (IF = 5.206)
  • Bláhová, L., Nováková, Z., Bláha, L., Večeřa, Z., Vrlíková, L., Dočekal, B., Dumková, J., Křůmal, K., Mikuška, P., Buchtová, M., Hampl, A., Hilscherová, K. (2019): The effects of nano-sized PbO on biomarkers of membrane disruption and DNA damage in sub-chronic inhalation study on mice. Nanotoxicology, 15:1-18 (IF = 5.811)
  • Dumková, J., Smutná, T., Vrlíková, L., Kotasová, H., Dočekal, B., Čapka, L., Tvrdoňová, M., Jakešová, V., Křůmal, K., Coufalík, P., Mikuška, P., Večeřa, Z., Vaculovič, T., Husáková, Z., Kanický, V., Hampl, A., Buchtová, M. (2020): Variability in the clearance of lead oxide nanoparticles is associated with alteration of specific membrane transporters. ACS Nano (IF = 15.881)
  • Bosakova M, Abraham SP, Nita A, Hruba E, Buchtova M, Taylor SP, Duran I, Martin J, Svozilova K, Barta T, Varecha M, Balek L, Kohoutek J, Radaszkiewicz T, Pusapati GV, Bryja V, Rush ET, Thiffault I, Nickerson DA, Bamshad MJ; University of Washington Center for Mendelian Genomics, Rohatgi R, Cohn DH, Krakow D, Krejci P (2020). Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling. EMBO Mol Med. 12(11):e11739. (IF=10.293)
  • Hampl M, Dumkova J, Kavkova M, Dosedelova H, Bryjova A, Zahradnicek O, Pyszko M, Macholan M, Zikmund T, Kaiser J, Buchtova M. (2020) Polarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon. Front Cell Dev Biol. 28;8:572. (IF=6.081)
  • Kimura T, Bosakova M, Nonaka Y, Hruba E, Yasuda K, Futakawa S, Kubota T, Fafilek B, Gregor T, Abraham SP, Gomolkova R, Belaskova S, Pesl M, Csukasi F, Duran I, Fujiwara M, Kavkova M, Zikmund T, Kaiser J, Buchtova M, Krakow D, Nakamura Y, Ozono K, Krejci P. An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice. Sci Transl Med. 2021 May 5;13(592):eaba4226. (IF=17.956)
  • Smutná T, Dumková J, Kristeková D, Laštovičková M, Jedličková A, Vrlíková L, Dočekal B, Alexa L, Kotasová H, Pelková V, Večeřa Z, Křůmal K, Petráš J, Coufalík P, Všianský D, Záchej S, Pinkas D, Vondráček J, Hampl A, Mikuška P, Buchtová M. Macrophage-mediated tissue response evoked by subchronic inhalation of lead oxide nanoparticles is associated with the alteration of phospholipases C and cholesterol transporters. Part Fibre Toxicol. 2022 Aug 3;19(1):52. (IF=9.112)
    Gonzalez Lopez M, Huteckova B, Lavicky J, Zezula N, Rakultsev V, Fridrichova V, Tuaima H, Nottmeier C, Petersen J, Kavkova M, Zikmund T, Kaiser J, Lav R, Star H, Bryja V, Henyš P, Vořechovský M, Tucker AS, Harnos J, Buchtova M, Krivanek J. Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development. Sci Adv. 2023 Aug 2;9(31):eadi0482. (IF=14.136)