Department of Animal Embryology, Cell and Tissue Diferentiation
Laboratory of Tumour Biology

Institute of Animal Physiology and Genetics, v.v.i.

Academy of the Sciences of the Czech Republic

Rumburska 89

277 21 Libechov

Czech Republic



Phone: +420 241 062 394
Fax: +420 315 639 510
E-mail: vannucci@biomed.cas.cz

1981	Degree in Medicine and Surgery (110/110) and National Professional Board at the University of Pisa, Pisa, Italy
1985	Winner at the selection for International Fellowships granted by the Rotary Foundation (Evanston, IL,USA), spent at the University of Chicago (Chicago, IL, USA)
1986 - 1987	Clinical Research Fellow at the Department of Surgery of the University of Chicago (Chicago, IL, U.S.A.)
1987	Diploma in experimental carcinogenesis with commendation for excellence after the course and training at The Ben May Laboratory for Cancer Research under the guide of Prof. C.B. Huggins, Nobel Laureate, Chicago, IL, U.S.A.
1987	Specialization diploma in General Surgery, University of Pisa, Pisa, Italy
1989 - 1990	Surgeon at the Division of General Surgery, St. Antony General Hospital, Fivizzano (MS), Italy
1991 - 2005	Surgeon and studentsˇ tutor at the Division of General and Transplantation Surgery, Department of Oncology, University of Pisa, Pisa, Italy
1991	Specialization diploma in Clinical Oncology, University of Milan, Milan, Italy
1991	Farini Award at the University of Padua (Italy) for research on cancer of GI tract
1995 - 2005	Visiting Professor at the Institute of Microbiology, Department of Immunology and Gnotobiology, Academy of Sciences of the Czech Republic, Prague, CZ
1998	Award of Italian Society for Microwaves şfor original anticancer surgical applicationsĄ
1998	University of Pisa Medical Faculty Studentsˇ Award for the best teaching and tutoring
2001 - 2007	Visiting Professor at the 1st Surgical Clinic, 1st Medical Faculty of the Charles University in Prague (oncology and experimental surgery teaching)
2004 - 2005	Researcher at the Department of Oncology, Transplantations and New Technologies in Medicine, University of Pisa, Italy
Since 2006	Scientist at the Institute of Microbiology, Laboratory of Natual Cell Immunity, Department of Immunology and Gnotobiology of the Academy of Sciences of the Czech Republic, v.v.i.
Since 2007	Scientist at the Institute of Animal Physiology and Genetics, Laboratory of Tumor Biology, Section of Animal Embryology and Cell and Tissue Differentiation of the Academy of Sciences of the Czech Republic, v.v.i.
2008	PhD diploma (immunology), Faculty of Natural Sciences, Charles University, Prague, (CZ)
2008	Award of the Italian Society for Microwaves (researches on antitumor hyperthermia), Pisa (IT)
2008	Award of the 13th World Congress on Advances in Oncology, Hersonissos, Crete (Greece)

experimental modelling of cancer in vivo, surgical models, anticancer immunomodulation, anticancer hyperthermia, microscopy of immune and cancer cell and tissues, study of tumor microenvironment

Principal investigator:
• GAAV 500200917 - Geneticka a imunologicka studie casnych stadii kolorektalniho adenokarcinomu: prostredi zanetu na konvencnich vs germ free zvirecich modelech a na vzorcich z lidske tkane. 2009 ­ 2013
• GAAV 500200510 - Hypertermie a protinadorova imunomodulace: morfofunkcni studie mikroprostredi u experimentalniho melanomu. 2005-2008
• Contract with ProtEra srl (156 0831), Sesto Fiorentino, Firenze (IT) for testing and development of new anticancer molecules in tumor models in vivo. 2005-2007

Collaborator:
• GAAVCR IAA500200509 Pospisil Regulation and modulation of the immune response
• GAAVCR IAA5020403 Bezouska Stress proteins and CD69
• GACR 524/ 04/ 0102 Horak Devitalization
• Research project: şThe effects of vagal nerve stimulation on tumour development & progressionĄ granted by Cyberonics, Houston, Texas, USA. Resitel: Y.Gidron, Ph.D., Associate Prof. of Medical Psychology, Univ. of Tilburg, The Netherlands; dalsi spoluresitel: Dr. B. Mravec, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, SK) (2006-2008)

Pospisil M., Feizi T., Fiserova A., Bezouska K., Vannucci L.: Pharmacological preparation containing oligosaccharide and application of this oligosaccharide. Czech patent No 296202, (2005)

ON PEER-REVIEWED JOURNALS WITH IF

• Michelassi F, Vannucci LE, Montag A, Chappell R, Rodgers J, Block GE.Ras oncogene expression as a prognostic indicator in rectal adenocarcinoma. J Surg Res 45(1): 15-20, 1988
• Michelassi F, Block GE, Vannucci L, Montag A, Chappel R.: A 5- to 21- year follow-up and analysis of 250 patients with rectal adenocarcinoma. Ann Surg 208(3): 379-389, 1988
• Michelassi F, Vannucci L, Ayala JJ, Chappel R, Goldberg R, Block GE: Local recurrence after curative resection of colorectal adenocarcinoma. Surgery 108(4): 787-92; discussion 792-3, 1990
• Michelassi F, Ewing C, Montag A, Vannucci L, Segalin A, Panozzo M, Bibbo M, Dytch H, Chieco-Bianchi P: Prognostic significance of ploidy determination in rectal cancer. Hepatogastroenterology 39(3): 222-5, 1992
• Falcone A, Cianci C, Pfanner E, Ricci S, Lencioni M, Brunetti I, Giulianotti PC, Vannucci L, Mosca F, Conte PF : Treatment of metastatic renal cell carcinoma with constant-rate floxuridine infusion plus recombinant alpha 2b-interferon. Ann Oncol 7(6): 601-605, 1996
• Pospisil M, Vannucci L, Horvath O, Fiserova A, Krausova K, Bezouska K, Mosca F. Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1. Int J Oncol 16(2): 267-76, 2000
• Fiserova A, Starec M, Kuldova M, Kovaru H, Pav M, Vannucci L, Pospisil M: Effects of D2-dopamine and alpha-adrenoceptor antagonists in stress induced changes on immune responsiveness of mice. J Neuroimmunol 130(1-2): 55-65, 2002
• Vannucci L, Fiserova A, Sadalapure K, Lindhorst TK, Kuldova M, Rossmann P, Horvath O, Kren V, Krist P, Bezouska K, Luptovcova M, Mosca F, Pospisil M: Effects of N-acetyl-glucosamine-coated glycodendrimers as biological modulators in the B16F10 melanoma model in vivo. Int J Oncol 23(2):285-96, 2003
• P. Boraschi, E. Neri, L. Vannucci, P. Vagli, G. Braccini, C. Bartolozzi: Double-contrast MR colonography: in vivo experimental study in an animal model. Med Sci Monit 9(10): BR363-9, 2003
• P. Krist, L. Vannucci, M. Kuzma, P. Man, K. Sadalapure, A. Patel, K. Bezouska, M. Pospisil, L. Petrus, TK. Lindhorst, V. Kren: Fluorescent labelled thiourea-bridged glycodendrons. Chembiochem 5(4): 445-52, 2004
• Vannucci L, Fiserova A, Horvath O, Rossmann P, Mosca F, Pospisil M: Cancer evolution and immunity in a rat colorectal carcinogenesis model. Int J Oncol 25(4): 973-81, 2004
• Bobek V, Boubelik M, Fiserova A, L'uptovcova M, Vannucci L, Kacprzak G, Kolodzej J, Majewski AM, Hoffman RM: Anticoagulant drugs increase natural killer cell activity in lung cancer. Lung Cancer 47(2): 215-23, 2005
• Strnadel J, Kverka M, Horak V, Vannucci L, Usvald D, Hlucilova J, Planska D, Vana P, Reisnerova H, Jilek F: Multiplex Analysis of Cytokines Involved in Tumour Growth and Spontaneous Regression in Rat Sarcoma Model. Folia Biologica (Praha) 53: 216-219, 2007
• Strnadel J, Kverka M, Reisnerova H, Hlucilova J, Usvald D, Vana P, Jilek F, Vannucci L a Horak V: Proteinove cipy v studiu expresie cytokinov na nadorovom modele - optimalizacia pripravy vzoriek. Chemicke listy 102, 269-273 (2008)
• Vannucci L, Stepankova R, Kozakova H, Fiserova A, Rossmann P, Tlaskalova-Hogenova H: Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affect the systemic immunity. Int J Oncol 32: 609-617 (2008)
• Vanek O, Nalezkova M, Kavan D, Borovickova I, Pompach P, Novak P, Kumar V, Vannucci L, Hudecek J, Hofbauerova K, Kopecky V Jr, Brynda J, Kolenko P, Dohnalek J, Kaderavek P, Chmelik J, Gorcik L, Zidek L, Sklenar V, Bezouska K: Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice. FEBS J 275(22):5589-606 (2008)
• Chernyavskiy O, Vannucci L, Bianchini P, Difato F, Saieh M, and Kubinova L: Imaging of mouse experimental melanoma in vivo and ex vivo by combination of confocal and nonlinear microscopy. Microscopy Research and Technique (accepted Dec.2008, in press)

All publications via PubMed


ON PEER-REVIEWED JOURNALS WITHOUT IF

• Togni P, Drizdal T, Vrba J and Vannucci L: Slot-line applicator for microwave hyperthermia. JMPEE on-line Dec. 22, 2008 www.jmpee.org ISSN 0832 7832
• Holubova M, Strnadel J, Usvald D, Klaudy J, Planska D, Vannucci L, Vana P, Reisnerova H, Jilek F, Horak V: Terapeuticka a patologicka fuze nadorovych bunek s imunitnimi bunkami – Nadorove vakciny versus nadorove hybridy. Bioprospect 3: 39-41 (2008)
• Vannucci L, Huggins CB, Mosca F: A new experimental model for colorectal cancerogenesis in the rat. J Environ Path Toxicol Oncol,13(1):59-61,1994
• Vannucci L., Pospisil M., Fiserova A.: NK cells, pregnancy, cancer. A short review. Pol J Gyn Invest 8 (4): 147-152, 2005 p-ISSN 1506-4794

CONFERENCE PAPERS (published in Books of Proceedings)

• Togni, P. - Vrba, J. - Vannucci, L.: Applicator for In-vivo Experiments on Mice with Melanoma Tumour. In Proceedings of the 14th Conference on Microwave Techniques COMITE 2008 [CD-ROM]. Praha: Československá sekce IEEE, 2008, p. 129-132. ISBN 978-1-4244-2138-1.
• Togni P, Vrba J and Vannucci L: System to Study the Effects of Microwave Hyperthermia on In-vivo Melanoma Model. EuMW2008 (European Microwave Week 2008 conferences), Amsterdam, The Netherlands, 27-31/10/08 (in press)
• Togni, P; Vrba, J; Vannucci, L: Hyperthermia applicator for small superficial tumor treatment . PROCEEDINGS of Progress in Electromagnetics Research Symposium (PIERS 2008), JUL 02-06, 2008, Cambridge (MA) USA, p. 775-779 (2008)
• Vrba, J; Togni, P; Visek, L, Vannucci, L, Peschke, P: Technical equipment for research of biological effects of EM field. PROCEEDINGS of Progress in Electromagnetics Research Symposium (PIERS 2008), MAR 24-28, 2008, Hangzhou PEOPLES R CHINA, Vol.1, p. 845-847 (2008)
• Pospisil M, Vannucci L, Luptovcova M, Svoboda J, Hulikova K, Kuldova M, Bezouska K, Pesta M and Fiserova A: The interaction of glycodendrimers with tumor microenvironment. Book of Proceedings of the 3rd International Conference on the Cancer Microenvironment Society, Prague, Czech Republic, October 12-16, 2004: Tumor Microenvironment: Progression, Therapy and Prevention. Medimond srl, Bologna, Italy; 2005, pp. 43-49, ISBN: 978-88-7587-135-2
• Vrba J, Vannucci, L, Peschke, P, Vozeh, F, Vojtisek, Kubes J, Herza J, Cvek, T, Drizdal, R, Zajicek: Technical Equipment for Research of EM Field and Biological Systems Interactions. In: Proceedings of the 13th Conference on Microwave Techniques - COMITE 2005. Praha: IEEE Czechoslovakia Section, 2005, p. 215-218. ISBN 80-86582-16-7
• Vrba J, Vannucci, L, Peschke, P, Vozeh, F, Vojtisek, M, Herza J, Cvek, T, Drizdal, R, Zajicek : Research of EM Field and Living Systems Interactions. In: Advanced Engineering Design AED 2006 [CD-ROM]. Prague (CZ): CTU, 2006, ISBN 80-86059-44-8.
• Vrba, J. - Vannucci, L. - Peschke, P. - Vozeh, F. - Vojtisek, M.: şTechnical Equipment for Research of EM Field and Biological Systems InteractionsĄ. PIERS (Progress in EM Research), Boston, Massachussetts, March 2006, Proceedings p.211­ 212, ISBN 1-933077-08-05
• Togni P, Vrba J, Vannucci L: Evaluation of an Equipment for Cancer Treatment Using Microwave Hyperthermia. Proceedings of the 37th European Microwave Conference, Munich, 8-12 October 2007, pp 1-3 [CD-ROM]
• Vannucci L, Fiserova A, Saieh M: A Paradoxical Hypothesis: Might a controlled immune suppression help to rescue the immune response in a pro-inflammatory tumor microenvironment? In: Book of Proceedings of the 4th International Conference of ICMS "Tumor Microenvironment: Progression, Therapy and Prevention" - (March 6-10, 2007, Florence, Italy), Medimond Srl, Bologna (IT). 2007, pp.79-83
• Strnadel, J., Kverka, M., Reisnerova H., Hlucilova J., Usvald D., Planska D., Vana P., Jilek F., Vannucci L., Horak V.: Proteinove cipy pri studiu expresie cytokinov na nadorovom modele: optimalizacia pripravy vzoriek. Chem. Listy 102, 269-273 (2008)
  
  
  268 citations on international journals

Since 2007

member of the editorial board of the journal: Molecular Medicine Reports. Editor: Prof. D.A. Spandidos, DSc, FRSH, Medical Faculty, University of Crete; Printer: Lichnia, Athens, Greece

TV
• Vednik: Imunoterapie (Czech Television 2) July, 2001, Czech Republic (M. Pospisil, L. Vannucci, A. Fiserova; reziser: V. Kunz)

Conferences for popularization of scientific arguments
• “L’Uovo di Colombo – Kolumbovo vejce” (28/11/2001 and 8-16-23-30/1/2002) Organizer of the series of Italian-Czech conferences for popularization of scientific arguments, in collaboration with the Italian Institute of Culture in Prague and the Intitute of Microbiology of the Academy of Sciences of the Czech Republic v.v.i., Narodni trida 3, Prague 1, Sal n.205.

• Fellow of the Czech Immunological Society
• Fellow of the European Society of Clinical Investigations
• Fellow of the International Cancer Microenvironment Society

• Member of Local Organizative Committee of the 3rd International Conference on the Cancer Microenvironment Society, Prague, Czech Republic, October 12-16, 2004
• Member of the Organizing Committee of the 5th Meeting of the European Mucosal Immunology Group EMIG, Prague, Czech Republic, October 5-7, 2006
• Member of Local Scientific Board of the 24th Annual Meeting of the ESHO - European Society for Hyperthermic Oncology, Prague, Czech Republic, June 13-16, 2007
• Member of Technical Program Committee of the PIERS2007 Progress In Electromagnetics Research Symposium, Prague, Czech Republic, August 27-30, 2007