Macholán Miloš, prof., RNDr., CSc.

Telephone: +420 532 290 138
Mobile phone:
Department: Laboratory of Mammalian Evolutionary Genetics
Building: Brno/
Institutional service phone:

Curriculum vitae:

1983 – 1988

Masaryk University (previously J.E. Purkyne University) in Brno, general biology

1988 – 1993

PhD at the Institute of Systematic and Ecological Biology of the Czechoslovak Academy of Sciences

1993 – 2005

researcher, Institute of Animal Physiology and Genetics, AS CR

1997 – 2001

head of Laboratory of Genetics and Embryology, IAPG


Associated Professor, Masaryk University in Brno, Systematic zoology and Ecology

2005 – present

senior researcher and head of the Laboratory of Mammalian Evolutionary Genetics


Professor of Zoology, MU Brno


Genetic and phenetic variation and systematics of small mammals, evolution of the genus Mus, hybridization and speciation in house mice



Dean’s Award (Masaryk University)


Kumpošt Award (best article, journal Vesmír)


Otto Wichterle Award for Young Scientists (ASCR)


Purkyně Award (best article, journal Živa)



Society of Systematic Biologists (member)


Society for Molecular Biology and Evolution (member)


European Society for Evolutionary Biology (member)

Internship abroad:


IEMEŽ, RAS, Moscow


University of Lausanne, Switzerland


Universita Roma II „Tor Vergata“, Italy



Božíková E, Munclinger P, Teeter KC, Tucker PK, Macholán M, Piálek J (2005) Mitochondrial DNA in the hybrid zone between Mus musculus musculus and Mus musculus domesticus: a comparison of two transects. Biol. J. Linn. Soc., 84: 363-378. PDF


Macholán M (2006) A geometric morphometric analysis of the shape of the first upper molar in mice of the genus Mus (Muridae, Rodentia). J. Zool., 269: 672-681. PDF


Macholán M., Munclinger P., Šugerková M. et al. (2007) Genetic analysis of autosomal and x-linked markers across a mouse hybrid zone. Evolution, 61: 746-771. PDF


Macholán M, Vyskočilová M, Bonhomme F, Kryštufek B, Orth A, Vohralík V (2007) Genetic variation and phylogeography of free-living mouse species (genus Mus) in the Balkans and the Middle East. Mol. Ecol., 16: 4774-4788. PDF


Piálek J, Vyskočilová M, Bímová B ... Macholán M et al. (2008) Development of unique house mouse resources suitable for evolutionary studies of speciation. J. Hered., 99: 34-44. PDF


Mikula O, Macholán M (2008). There is no heterotic effect upon developmental stability of the ventral side of the skull in the Mus musculus musculus/M. m. domesticus hybrid zone. J. Evol. Biol., 21: 1055–1067. PDF


Macholán M, Baird SJE, Munclinger P, Dufková P, Bímová B, Piálek J (2008) Genetic conflict outweighs heterogametic incompatibility in the mouse hybrid zone? BMC Evol. Biol., 8: 271. PDF


Bímová B, Albrecht T, Macholán M, Piálek J (2009) Signalling components of the house mouse mate recognition system. Behav. Process., 80: 20-27. PDF


Mikula, O., Auffray, J.-C., Macholán, M., 2010: Asymmetric size and shape variation in the Central European transect across the house mouse hybrid zone. Biol. J. Linn. Soc., 101: 13-27. PDF


Dufková P, Macholán M, Piálek J (2011) Inference of selection and stochastic effects in the house mouse hybrid zone. Evolution, 65: 993–1010. PDF


Macholán M, Baird SJE, Dufková P, Munclinger P, Vošlajerová Bímová B, Piálek J (2011) Assessing multilocus introgression patterns: A case study on the mouse X chromosome in Central Europe. Evolution, 65: 1428-1446. PDF


Vošlajerová Bímová B, Macholán M, Baird SJE et al. (2011) Reinforcement selection acting on the European house mouse hybrid zone. Mol. Ecol., 20: 2403-2424. PDF


Wang L, Luzynski K, Pool J ... Macholán M et al. (2011) Measures of linkage disequilibrium among neighboring SNPs indicate asymmetries across the house mouse hybrid zone. Mol. Ecol., 20: 2985-3000. PDF


Janoušek, V., Wang, L., Luzynski, K., Dufková, P., Mrkvicová Vyskočilová, M., Nachman, M.W., Munclinger, M., Macholán, M., Piálek, J., Tucker, P.K., 2012: Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus. Mol. Ecol., 21: 3032-3047. PDF


Baird, S.J.E., Macholán, M., 2012: What can the Mus musculus musculus/M. m. domesticus hybrid zone tell us about speciation? In Macholán, M., Baird, S.J.E., Munclinger, P., Piálek, J. (eds.): Evolution of The House Mouse. Cambridge Studies in Morphology and Molecules: New Paradigms in Evolutionary Biology. Cambridge University Press, Cambridge, pp. 334-372. PDF

Baird, S.J.E., Ribas, A., Macholán, M., Albrecht, T., Piálek, J., Goüy de Bellocq, J., 2012: Where are the wormy mice? A re-examination of hybrid parasitism in the European house mouse hybrid zone. Evolution, 66(9): 2757-2772. PDF

Albrechtová, J. ; Albrecht, T. ; Baird, S. J. E. ; Macholán, M. ; Rudolfsen, G. ; Munclinger, P. ; Tucker, P. K. ; Piálek, J., 2012: Sperm-related phenotypes implicated in both maintenance and breakdown of a natural species barrier in the house mouse. Proceedings of the Royal Society of London. B - Biological Sciences, 279(1748): 4803-4810. PDF


Ďureje, Ľ., Macholán, M., Baird, S.J.E., Piálek, J., 2012: The mouse hybrid zone in Central Europe: from morphology to molecules. Folia Zool., 61(3-4), 308-318. PDF


Hiadlovská, Z., Strnadová, M., Macholán, M., Vošlajerová Bímová, B., 2012: Is water really a barrier for the house mouse? A comparative study of two mouse subspecies. Folia Zool., 61(3-4), 319-329. PDF


Macholán, M., Mrkvicová Vyskočilová, M., Bejček, V., Šťastný, K., 2012: Mitochondrial DNA sequence variation and evolution of Old World house mice (Mus musculus). Folia Zool., 61(3-4), 284-307. PDF


Hiadlovská, Z., Vošlajerová Bímová, B., Mikula, O., Piálek, J., Macholán, M., 2013: Transgressive segregation in a behavioural trait? Explorative strategies in two house mouse subspecies and their hybrids. Biol. J. Linn. Soc., 108(1): 225-235. PDF


Zima, J., Arslan, A., Benda, P., Macholán, M., Kryštufek, B., 2013: Chromosomal variation in social voles: a Robertsonian fusion in the Guenther's vole. Acta Theriol., 58(3): 255-265. PDF


Kváč, M., McEvoy, J., Loudová, M., Stenger, B., Sak, B., Květoňová, D., Ditrich, O., Rašková, V., Moriarty, E., Rost, M., Macholán, M., Piálek, J., 2013: Coevolution of Cryptosporidium tyzzeri and the house mouse (Mus musculus). Int. J. Parasitol., 43: 805-817. PDF


Fornuskova, A., Bryja, J., Vinkler, M., Macholán, M.,Piálek, J. 2014: Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies. Ecol. Evol. 4: 2931-2944. PDF

  Hiadlovská, Z., Macholán, M., Mikula, O., Vošlajerová Bímová, B. 2014: The meek inherit the earth: less aggressive wild mice are more successful in challenging situations. Biol. J. Linn. Soc. 113: 310-319. PDF





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