RNDr. Petr Šolc, Ph.D.

Date and place of birth: 15. 1. 1981, Melnik, Czech Republic



2005-2009 Ph.D., developmental biology - Faculty of Science, Charles University, Prague;
Doctoral thesis: Cell signaling pathways controlling meiotic maturation of mammalian oocytes
1999-2005 Faculty of Science, Charles University,Prague, Developmental Biology (MSc.)
Diploma thesis: Role of Protein Kinase B during mouse resumption of meiosis


Professional experience

2013-now Research group leader of Laboratory of DNA integrity, IAPG CAS
2009-2013 Post-doc, Laboratory of Cell Regeneration and Plasticity, IAPG CAS
2005-now External teacher, Dept. of Cell Biology, Faculty of Science, Charles University


International training courses and short stays

05/2013 EMBL Master Course, Bioimage Data Analysis, EMBL Heidelberg, Germany
09/2010 Department of Biology, University of Pennsylvania, USA, Richard Schultz and Mike Lampson labs, short stay focused on FRET kinase biosensors
11/2007 European Molecular Biology Laboratory, Heidelberg, Germany, Jan Ellenberg group, short stay, topic: live-cell imaging of oocytes, supported by EMBO short-term fellowship: „CDC25A and CDC25B dynamics during meiotic maturation in the mouse oocytes“
06/2007 EMBO practical Course on Quantification of Target Sequences by qPCR, EMBL Heidelberg, Germany


Teaching Activities

Lectures at Universities

2005-now semester course, Molecular Mechanisms of the Cell Cycle Regulation, Faculty of Science, Charles University, Prague
2017 selected talks in Reproductive Medicine and Genetics course, Second Faculty of Medicine, Charles University, Prague

Ph.D. and Diploma thesis supervisions

  • Present: supervision of three Ph.D. theses and one diploma thesis.
  • Past: supervision of one defended Ph.D. thesis, 2 defended diploma thesis and 2 defended bachelor thesis.


Administrative experience and faculty responsibilities

2014-now Internal member of the Scientific Board, Centre Pigmod
2012-2017 Vice-head of Council of Inst. of Animal Physiology and Genetics CAS


Service to scientific community

  • Review manuscripts:
    • Developmental Dynamics
    • Molecular and Cellular Biology
    • Cloning and Stem Cells
    • Reproduction
    • Fertlity and Development
    • Plos One
  • Ad hoc reviewer of project proposals and theses for Charles University, Prague
  • Review of project proposal for Research Councils UK.


International cooperation

  • prof. Richard Schultz, University of Pennsylvania and University of California, Davis, USA.
    Common topics: Cell cycle regulation in mouse oocytes and embryos
    6 collaborative papers, collaborative grant (2012-2015)
  • Tomoya Kitajima, Ph.D., RIKEN Center for Developmental Biology, Japan
    Common topics: Chromosome dynamics and advance live cell imaging techniques
    2 collaborative papares
  • prof. Jan Ellenberg, The European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
    Common topics: Live cell imaging of mouse oocytes and early embryos
    one collaborative paper
  • Vladimir Baran, Ph.D., Institute of Animal Physiology, Slovakia
    Common topics: Cell signaling in mouse oocytes and embryos, confocal microscopy
    9 common papers
  • Karen Schindler, Ph.D., Department of Genetics, Rutgers, The State University of NJ, USA
    Common topic: Chromosome missegregation in infertility
    one collaborative paper, collaborative grant under review


Membership in academic councils and editorial boards

since 2015 member of The Czechoslovak Microscopy Organization
since 2014 member of the European Society of Human Reproduction and Embryology
since 2012 head of Section of Developmental and Reproduction Biology, Czechoslovak Biological Society


Grants (PI position)

2012-2015 The signaling pathways synchronizing nuclear envelope break down, chromosome condensation a spindle formation during mammalian meiosis of oocytes, Ministry of Education, program Kontakt II, LH12057
2010-2013 Role of CDC25B phosphatase during cell cycle resumption: The comparison of meiotic resumption in oocytes and G2 checkpoint recovery in somatic cells, GACR, P301/11/P081


Lectures and seminars (last five years)

2016 Chromosome integrity and dynamics during oocyte meiotic maturation. University of California, Davis, hosted by Richard Schultz, December 8th, 2016
  DNA damage response during mouse oocyte maturation. Rutgers University, hosted by Karen Schindler, December 2nd, 2016
  Chromosome integrity and dynamics during oocyte meiotic maturation. Johns Hopkins Medicine, Baltimore, USA, hosted by Rong Li, November 28th, 2016
2015 Multiple requirements of PLK1 during mouse oocyte maturation. Live cell confocal microscopy – new dimension for 21st century. March 11th-13th, 2015, Kosice, Slovakia
  PLK1 as a key regulator of oocyte meiotic maturation. DNA Analysis XII, June 11th, 2015, 1st Faculty of Medicine, Charles University
2014 Multiple requirements of PLK1 during mouse oocyte maturation. Rutgers University, NJ, USA, hosted by Karen Schindler, December 12th, 2014.
  Multiple requirements of PLK1 during mouse oocyte maturation. University of California, Davis, CA, USA, hosted by Richard Schultz, December 4th, 2014.
2012 Check-point kinase I (CHK1) and Polo-like kinase I (PLK1) control multiple aspects of oocytes maturation. Ovarian club II, Prague, November 8th-11th, 2012
  Polo-like Kinase I Controls Nuclear Envelope Break Down and Chromosome Dynamics in Meiosis I. SRD-NIAS the 2nd Japan-Czech Joint Symposium “Understanding the Germ Cell Potential”, Tokyo, Japan, September 10th, 2012



Full bibliography in Pubmed collection in total 14 papers in impacted journals including 6 papers with corresponding author position.